New User? Sign Up  |  Sign In  |  Help
“Logo
 

                 LogoLogo

Question
Answer
Discover
     
Search for questions :
My Profile

philosopher

Open Questions Bookmark and Share

Can this research help scientist better understand brain developement and what goes wrong in autistic brains?

Emerging tools and techniques that may advance autism research
Baby brain: Novel lab-grown ‘mini-brains’ mimic specific regions of the human brain; they contain both neurons (green) and support cells called glia (purple).

Photographs courtesy of Fikri Birey, Pasca Laboratory, Stanford University
Two new methods for building ‘mini-brains’ may help researchers study how early brain development differs in people with autism.
One method enables scientists to recreate specific brain regions rather than an entire brain1. The other reduces the time and cost to make a mini-brain, promising to boost sample sizes from a few organoids per study to hundreds2.
Scientists typically make brain organoids by transforming cells from a person’s skin, blood or urine into stem cells capable of turning into almost any cell type. They then use chemicals to transform the stem cells into brain-cell precursors, and let them mature.
The resulting mixture of cells is often unpredictable, however, so it does not mimic the composition of any particular brain region.
In one of the new studies, researchers created mini-brains that resemble either the dorsal forebrain or the ventral forebrain, two regions of the developing brain.
The researchers use a multi-step process: They coax stem cells to become brain-cell precursors in a standard way. They then use a chemical cocktail to shape the precursors into a specific mixture of cells characterizing either the dorsal or ventral forebrain.
The brain-like blobs can be kept alive for more than two years, maturing long enough to develop the cell types, activity patterns and gene-expression profiles of a typical human brain after birth.
The researchers allow the mini-brain regions to fuse by suspending two of them in the same tube. The fusion enables researchers to study how brain regions form connections and communicate. The report was published in September in Nature Protocols.

Emerging connections: Fusing mini-brains in culture may reveal how brain regions interact in early development.
Pasca Laboratory, Stanford University
Mix-and-match:
The approach may also help reveal how neurons’ migration goes awry in autism.
Neurons that dampen brain activity in the ventral region typically travel to dorsal areas during brain development. In autism, these inhibitory neurons do not migrate properly3. The fused mini-brain regions may help researchers better understand this movement and how it differs in autism.
In a separate study, scientists drastically cut the time it takes to build a mini-brain. The researchers discovered that they could boost the proportion of stem cells that mature into brain cells if they started transforming the cells earlier — after letting
See link.
https://www.spectrumnews.org/news/toolbox/new-techniques-extend-tool-kit-constructing-mini-brains/

66 day(s) ago

    Comment(s) (0)
    Report
   Like  
   Email to Friends  
   Bookmark  
   Subscribe to Answer Alerts  
No comments yet !     Be the first to comment !
Answers (1)

Kravenhead
It sounds like it.
It also sounds like the new process of creating these organoid mini brains is much cheaper than what was being used. Time and cost are huge factors in research and the development of treatments.
Lower costs allow more heads to work on any given issue and attracts investors.


Posted 66 day(s) ago

( 1 )
( 0 )
    Comment(s) (2)
   Report

Kravenhead
65 day(s) ago
Yeah, I know. I think they're being cheap in not having staff to do that.

philosopher
65 day(s) ago
As you know Spectrum never answers questions.

Edit your answer. Click save, when done.
Question Title Can this research help scientist better understand brain developement and what goes wrong in autistic brains?
Your Answer
  |         |                            
bold  italic  underline  strike       big  small       superscript  subscript 
  Allows to add a link.
Caption :
Link URL :
( Must starts with "http://" )
Add  |   Cancel
  Allow to insert an image. Must be among the following file types - *.jpg, *.gif, *.png & *.bmp.
Image Url :   Upload New
( Image url must always starts with " http:// " )
Width : pixels
( Must not be greater than 450px. Enter 0px for no resize )
Add  |   Cancel
  Allow to insert YouTube video. Insert the video embed code.
Embed Code :
Add  |   Cancel
Character Count ( Max. - 5000 ) : 2969
  Your comment on this question
  |         |                            
bold  italic  underline  strike       big  small       superscript  subscript 
  Allows to add a link.
Caption :
Link URL :
( Must starts with "http://" )
Add  |   Cancel
  Allow to insert an image. Must be among the following file types - *.jpg, *.gif, *.png & *.bmp.
Image Url :   Upload New
( Image url must always starts with " http:// " )
Width : pixels
( Must not be greater than 450px. Enter 0px for no resize )
Add  |   Cancel
  Allow to insert YouTube video. Insert the video embed code.
Embed Code :
Add  |   Cancel
Max Allowed : 5000 Characters Current Count : 0
  Your comment on this answer
  |         |                            
bold  italic  underline  strike       big  small       superscript  subscript 
  Allows to add a link.
Caption :
Link URL :
( Must starts with "http://" )
Add  |   Cancel
  Allow to insert an image. Must be among the following file types - *.jpg, *.gif, *.png & *.bmp.
Image Url :   Upload New
( Image url must always starts with " http:// " )
Width : pixels
( Must not be greater than 450px. Enter 0px for no resize )
Add  |   Cancel
  Allow to insert YouTube video. Insert the video embed code.
Embed Code :
Add  |   Cancel
Max Allowed : 5000 Characters Current Count : 0
Email this question link to friends
You must enter an email-address, if a name is entered and vice-versa for each friend.
Friend #1 -
Friend #2 -
Friend #3 -
Friend #4 -
Friend #5 -
Enter Security Code : *

 

Copyright ©  All rights reserved.

Contact Us   Terms of Use