Can T Cells be engineered to be T cell engaging bi specific antibodies and destroy cancer?
Dubbed "T-cell engaging bi-specific antibodies," these cancer combatants attack malignant cells but leave healthy cells untouched. That's thanks to their selective targeting system, which zeroes in on a protein found on the surface of several types of cancer cells called ROR1, and also thanks to their talent for binding with T cells, the big guns of the immune system.
"Once the T cells are recruited and activated, they release cytotoxic molecules that penetrate the target cells and kill them," Rader says. "Natural antibodies can't do this. You have to engineer them in a bi-specific fashion to do this."
21 day(s) ago